Table 2.

Heteroplasmic Polymorphisms in DCM Patients

Base change	Gene	RE +/−	RE digestion*		Mutant %		DCM	Controls
			Mutant	Wild Type	Blood	Heart
T4336C†	tRNA GlnC	AvaII +	153bp+200bp	353 bp	50	72	1 /85	0 /111
T10034C‡	tRNA Gly	AluI +	110bp+117bp	227 bp	75	90	1 /85	0 /111
A10398G‡-Thr Ala	ND3	DdeI+	37bp+38bp+160bp	37 bp+ 198 bp	58	75	1 /85	0 /111

RE +/−, restriction enzyme gain or loss.

* Fragment size in mutant and wild-type DNA after restriction enzyme (RE) digestion.

^† Described as a polymorphism in LHON patients and in normal controls. 41

^‡ Reported as neutral polymorphisms in encephalomyopathy patients and in normal controls. 42