Figure 2.

Lymph node demonstrates paracortical expansion by CD3⁺ DN T cells. Immunoperoxidase stains (ABC immunoperoxidase technique, hematoxylin counterstain; original magnification, ×200) performed in paraffin sections demonstrates expansion of interfollicular regions by CD3⁺ T cells (A) that are largely CD4⁻ (B) and CD8⁻ (C). Most CD4⁺ cells are within germinal centers. The paracortex contains numerous lymphocytes positive for CD57 (D) and TIA-1 (E) with weaker and patchy staining for perforin (F).