Table 3.

Summary of Peripheral Blood Lymphocyte Phenotype, CD95 Mutations and Lymphocyte Apoptosis Defects

Patient	Lymphocytes (cells/mm3)	T cells (%)
		CD3	CD3/CD4	CD3/CD8	CD3/CD4−CD8−	CD57	CD57/CD8	αβ DN T cells	γδ DN T cells	DN T/CD45RA	% of DN T cells
1	11,700	66	24	23	18	34	14	14	1	ND	ND
2	5,712	65	11	16	39	42	22	29	3	29	74
3	7,740	68	31	27	10	23	12	6	1	8	80
4	1,870	70	23	37	9	39	16	4	3	ND	ND
5	1,680	55	15	20	20	26	15	5	3	ND	ND
6	12,328	67	15	26	26	32	22	13	8	ND	ND
11	3,105	73	27	13	33	52	16	27	1	ND	ND
14	5,900	59	14	27	17	15	8	7	10	ND	ND
17	2,950	74	19	25	29	53	23	24	1	23	79
20	810	76	31	29	14	29	16	9	3	8	57
Normal range	1,173–2,640	61–84	32–58	11–36	1–7	5–29	3–24	<1	<5	<3	NA

Activation markers (%)		B cells (%)			NK cells (%)		CD95 mutation	Lymphocyte apoptosis defect
CD3/HLA-DR	CD3/CD25	CD20	CD20/CD5	% of CD20 cells	CD16/CD56	CD16/CD56/CD3
46	11	27	21	76	3	3	+	+
44	18	31	25	81	4	8	+	+
17	7	24	22	92	5	3	+	+
15	8	26	18	69	3	10	+	+
ND	ND	41	38	92	4	7	+	+
33	3	14	7	50	17	3	+	+
57	5	17	15	90	6	7	−	+
22	10	43	38	90	3	11	−	+
56	4	20	10	50	4	1	+	+
35	11	19	14	74	4	13	+	+
<15	<37	5–16	1–10	NA	6–30	1–15	Negative	Negative

ND: Not determined; NA, not available.

*Percentage of DN T cells that also express CD45RA.

^†Percentage of CD20 cells that also express CD5.