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Immunolabeling of the hippoccampus (vibratome sections) in a 6-month-old transgenic mouse (A, B, and C) and in a control mouse (D). A and D: human specific TP20 antibody to tau; B: phosphorylation-dependent AT180 antibody to tau; C: tau-1 antibody to tau. A proportion of pyramidal cells in Ammon’s horn of the transgenic mouse show an accumulation of transgenic tau and AT180-immunoreactive phosphorylated tau in their somatodendritic compartment. Scale bar, 50 μm.
