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. 1999 Jan;154(1):255–270. doi: 10.1016/S0002-9440(10)65272-8

Figure 5.

Figure 5.

Immunolabeling on the entorhinal cortex in a 7-month-old transgenic mouse. A and B: Double immunolabeling with the human specific anti-tau antibody (TP20) (A) and with the phosphorylation-dependent AT180 anti-tau antibody (B). The same neurons show an accumulation of transgenic tau and of AT180-immunoreactive phosphorylated tau in their somatodendritic compartment. C and D: Double immunolabeling with the TP20 antibody (C) and with the α-tubulin antibody (D). The neurons expressing the transgenic tau do not show increased tubulin immunoreactivity. Scale bar, 40 μm (A and B), 20 μm (C and D).