Table 2.
Clinical Data and c-kit Mutations of the Benign GISTs Analyzed in this Study
| Case | Age/Sex | Location | Cell type | Tumor size or maximum diameter (cm) | Status and follow-up in months | c-kit mutant band | Sequencing of exon 11 of c-kit |
|---|---|---|---|---|---|---|---|
| 1 | 68 /M | Stomach | Spindle | 2.0 | NED 27 | − | Not done |
| 2 | 66 /M | Stomach | Spindle | 3–4 | − | Not done | |
| 3 | 69 /M | Stomach | Epithelioid | 3–4 | − | Not done | |
| 4 | 63 /M | Stomach | Spindle | 3.5 | − | Not done | |
| 5 | 64 /F | Stomach | Spindle | 3.6 | NED 21 | − | Wild-type |
| 6 | 60 /F | Stomach | Spindle | 4× 4× 3 | − | Wild-type | |
| 7 | 57 /M | Stomach | Spindle | 4 | NED 56 | − | Not done |
| 8 | 70 /F | Stomach | Spindle* | 4.5× 4.5× 3.5 | NED 25 | − | Wild-type |
| 9 | 40 /M | Stomach | Epithelioid | 5 | NED 34 | − | Wild-type |
| 10 | 33 /M | Stomach | Spindle | 5× 3.5× 3.5 | NED 44 | + | Deletion |
| 11 | 61 /F | Stomach | Epithelioid | 5× 5 | NED 35 | − | Wild-type |
| 12 | 79 /F | Stomach | Spindle* | 8 | NED 58 | − | One point mutation |
| 13 | 45 /F | Stomach | Spindle | 9 | NED 24 | − | Two point mutations |
| 14 | 69 /M | Small bowel | Spindle | 2.5× 2.0× 2.0 | NED 8 | − | Not done |
| 15 | 35 /F | Small bowel | Spindle | 3–4 | − | Wild-type | |
| 16 | 57 /M | Small bowel | Epithelioid | 4 | NED 54 | − | Wild-type |
| 17 | 80 /M | Small bowel | Spindle | 4.5 | NED 31 | − | Not done |
| 18 | 60 /M | Small bowel | Spindle | 6× 6× 6 | − | Not done | |
| 19 | 52 /M | Small bowel | Spindle | 7 × 7× 6.5 | NED 27 | − | Not done |
NED, no evidence of disease.
*Case 8 showed 2 mitoses/10 HPF and case 12 showed 3 mitoses/10 HPF. All other cases showed ≤1 mitosis/10 HPF.