Table 3.
Clinical Data and c-kit Mutations of the Malignant and Potentially Malignant GISTs Analyzed in this Study
| Case | Age/Sex | Location | Cell type | Tumor size or maximum diameter (cm) | Mitoses/ 10 HPF | Clinical behavior, follow-up (months) | c-kit mutant band | Sequencing of exon 11 of c-kit |
|---|---|---|---|---|---|---|---|---|
| 20* | 62 /M | Stomach | Spindle | 15 | 2 | Died of lung cancer, 36 months. No evidence for IAR | + | Deletion |
| 21* | 80 /F | Stomach | Epithelioid | 5.5× 3.5× 1.7 | <1 | + | Deletion | |
| 22* | 72 /M | Stomach | Epithelioid | 11× 10× 3.5 | <1 | − | Wild type | |
| 23 | 26 /F | Stomach | Epithelioid | 6× 4.5× 2.5 | 18 | − | Wild type | |
| 24 | 47 /F | Stomach | Spindle | 10× 6× 5 | 11 | Omental seeding at present-ation. IAR at 15 months | + | Deletion |
| 25 | 57 /M | Stomach | Spindle | 9× 7.5× 7 | 12 | Mediastinal metastasis at presentation | − | Not done |
| 26 | 70 /M | Stomach | Spindle | 11× 5 | 18 | Omental seeding at presentation. IAR at 25 months | + | Deletion+ PM |
| 27 | 69 /F | Stomach | Spindle | 12 | 9 | NED 6 months | + | Deletion |
| 28 | 44 /M | Stomach | Epithelioid | 17 × 10× 5 | 9 | IAR at 25 months | − | Wild type |
| 29 | 44 /M | Stomach | Spindle | 17 | 6 | − | Deletion | |
| 30 | 63 /M | Stomach | Spindle | 19× 12× 7 | 8 | + | D+ 3 PM | |
| 31 | 41 /M | Stomach | 39× 18 | 30 | Alive with disease, 16 months | − | Not done | |
| 32 | 50 /M | SB | Spindle | 6.5× 4.5× 3.4 | 11 | Liver metastasis at presentation | + | Deletion |
| 33 | 68 /M | SB | Spindle | 7× 6 | 8 | IAR at 16 months | − | Not done |
| 34 | 60 /M | SB | Spindle | 7 | 6 | IAR at 12 months DOD 24 months | + | Deletion |
| 35 | 64 /F | SB | Spindle | 12–15 | >20 | DOD 15 months | − | Wild type |
| 36 | 54 /M | SB+ mesentery | Spindle | 15× 13× 6 | 15 | IAR 8 months | − | Wild type |
| 37 | 85 /M | SB | Spindle | 30× 30× 5 | 15 | DOD 16 months | − | PM |
| 38 | 63 /M | Rectum | Spindle | 7 | 13 | NED 20 months | − | PM |
| 39 | 73 /M | Rectum | Spindle | 10× 9× 8 | 10 | + | Deletion | |
| 40 | 62 /F | IAR (2 yrs) | Spindle | 2 kg, multiple tumors | IAR 2 and 3 years after a gastric GIST | + | Deletion | |
| 41 | 56 /F | IAR (5 yrs) | Spindle | >20 cm | IAR 4 and 5 years after a total gastrectomy for gastric malignant GIST | − | Wild type | |
| 42 | 59 /F | Liver metastasis | Spindle | 8 cm | Liver metastasis 4 years after malignant gastric GIST | + | Deletion | |
| 43 | 64 /M | Liver metastasis | Spindle | 6 cm | Liver metastasis 6 months after SB GIST | − | Not done |
*Cases classified as potentially malignant.
DOD, died of disease; NED, no evidence of disease; SB, small bowel; IAR, intra-abdominal recurrence; D, deletion; PM, point mutation.