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Progressive enlargement of alveolar macrophages from SP-D (−/−) mice. (A) Increased numbers of normal-appearing macrophages were observed by 2 weeks of age in SP-D (−/−) mice. (B) Enlarged, foamy, alveolar macrophages were readily observed by 3 weeks of age in SP-D (−/−) mice. (C) By 6 weeks of age, multiple foci of large, foamy, alveolar macrophages were observed throughout the lungs of SP-D (−/−) mice. (Scale bar = 30 μm.)
