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. 1989 May;97(1):16–18. doi: 10.1111/j.1476-5381.1989.tb11918.x

Pertussis toxin prevents the inhibitory effect of adenosine and unmasks adenosine-induced excitation of mammalian motor nerve endings.

E M Silinsky 1, C Solsona 1, J K Hirsh 1
PMCID: PMC1854458  PMID: 2720305

Abstract

Pertussis toxin (PTX), which blocks certain classes of guanine nucleotide binding proteins (G proteins), consistently blocked the inhibitory effects of adenosine (100 microM-250 microM) on quantal acetylcholine (ACh) secretion in rat phrenic nerve hemidiaphragm preparations. PTX pretreatment also highlighted long-lasting increases in evoked ACh release elicited by adenosine. The results suggest that specific G proteins are involved in mediating the inhibitory effects of adenosine at motor nerve endings.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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