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. 2000 May 16;97(11):5984–5988. doi: 10.1073/pnas.100113397

Figure 1.

Figure 1

High-affinity iron uptake in yeast. Insoluble, extracellular Fe(III) is reduced to Fe(II) by the plasma membrane ferric reductases Fre1 and Fre2. Iron is then transported into the cell by a plasma membrane complex consisting of the multicopper oxidase Fet3 and the iron permease Ftr1. Ftr1 transports Fe(III), and Fet3 oxidizes Fe(II) to Fe(III) to allow transport by Ftr1. Fet3 requires copper for activity. The copper transporter Ccc2 is required for the copper-loading of Fet3 in the late Golgi.