Table 1.

Tpk2 regulates the high-affinity iron-uptake pathway

Gene	Function
High-affinity iron uptake
Fre1	Ferric reductase, plasma membrane
Fre2	Ferric reductase, plasma membrane
Fet3	Multicopper ferroxidase, plasma membrane
Ftr1	Iron permease, plasma membrane
Ccc2	Copper transporter
Low-affinity iron uptake
Fet4	Low-affinity Fe(II) transporter
Vacuole iron transport
Fth1	Vacuolar iron transporter, FTR1 homolog
Fet5	Multicopper oxidase, vacuole
Mitochondrial iron homeostasis
Atm1	ABC transporter, mitochondria
Yfh1	Yeast frataxin homolog
Putative iron transporters
Sit1	Siderophore iron transport
Arn1	MFS/MDR family
Yol158c	MFS/MDR family
Yhl047c	MFS/MDR family

Proteins involved in iron transport are listed above. Those shown in bold are negatively regulated by Tpk2. ABC, ATP-binding cassette; MFS/MDR, major facilitator super family/multidrug resistance.