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. 1989 Aug;97(4):993–995. doi: 10.1111/j.1476-5381.1989.tb12552.x

Streptozotocin-induced diabetes reduces the density of [125I]-endothelin-binding sites in rat cardiac membranes.

W G Nayler 1, J J Liu 1, S Panagiotopoulos 1, D J Casley 1
PMCID: PMC1854608  PMID: 2676060

Abstract

The effect of acute, streptozotocin-induced diabetes on the affinity (KD), density (Bmax) and selectivity of specific, high affinity binding sites for [125I]-endothelin [( 125I]-ET) in rat cardiac membrane fragments was determined. Three days after a single i.v. bolus dose of streptozotocin (60 mg kg-1), the density of [125I]ET binding sites was reduced (P less than 0.01) without changes in affinity or selectivity.

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Selected References

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