Figure 3.

Histologic sections of murine lungs. Normal airways and vessels after sensitization with OVA and exposure to nebulized PBS in WT mice (A) and IL-10−/− mice (B). Representative sections after sensitization and challenge with OVA from a WT mouse (C) and an IL-10−/− mouse (D). Cellular infiltration can be seen perivascularly and to some extent peribronchially. PAS-stained section from a WT mouse (E) and an IL-10−/− mouse (F) sensitized and challenged with OVA. Note the staining of single goblet cells within the respiratory epithelium. PAS-stained section from an IL-10−/− mouse sensitized and challenged with OVA and administered IL-10 by adenovirus-mediated gene transfer. Hyperplasia of goblet cells and excessive mucin production partly filling the airway lumen can be seen in a WT mouse (G) and an IL-10−/− mouse (H).