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Immunohistochemical staining for vWF (A, B), CD31 (C, D), and α-SMA (E–H) on paraffin sections of liver (A, E), lung (B, F), kidney (C, G), and heart (D, H), demonstrating normal blood vessel morphology in organs of adult Sm22-Cre+/0;Smad5fl/− mice. All veins of Sm22-Cre+/0;Smad5fl/− mice are lined with ECs, and all arteries contain α-SMA-positive cells, comparable with control mice (not shown). Original magnifications, ×200.
