Figure 5.

Neointimal lesion development in the arteries of control mice (Ctrl; A, B, E, F, I, J) and Sm22-Cre^+/0;Smad5^fl/− mice (Sm22KO; C, D, G, H, K, L) 28 days after ligation of the left carotid artery. A–D: Representative pictures of transverse sections stained with H&E demonstrating no difference in neointimal lesion development between control mice and mutant mice. In control mice as well as in mutant mice, the cells in the intimal lesion are mainly positive for α-SMA (E–H), but also vWF-positive cells can be observed (I–L). Original magnifications, ×200.