Table 1.
Overrepresentation Analysis of Annotated Ricin-Induced Gene Expression in Lung
| Gene ontogeny group | Hits | Total in category | P value (EASE score) |
|---|---|---|---|
| Biological process | |||
| Defense response | 34 | 429 | 4.05e-15 |
| Response to pathogen | 24 | 194 | 1.24e-14 |
| Immune response | 30 | 343 | 2.31e-14 |
| Innate immune response | 16 | 193 | 8.01e-12 |
| Inflammatory response | 15 | 90 | 6.92e-11 |
| Response to wounding | 18 | 162 | 3.45e-10 |
| Response to stress | 28 | 450 | 6.46e-10 |
| Response to chemical substance | 13 | 115 | 1.72e-07 |
| Chemotaxis | 11 | 76 | 2.15e-07 |
| Cell motility | 13 | 154 | 4.02e-06 |
| Molecular function | |||
| Cytokine activity | 21 | 167 | 2.11e-13 |
| Chemokine activity | 11 | 35 | 3.79e-11 |
| G-protein receptor binding | 11 | 37 | 7.02e-11 |
| Receptor binding | 25 | 371 | 4.44e-10 |
| Growth factor activity | 12 | 121 | 1.25e-06 |