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Efficacy of TACE inhibitor (TNF484) and antibiotic (ceftriaxone) treatments on outcome of wt and TLR2-/- S. pneumoniae infected mice. Survival rate in wt (n = 15) and TLR2-/- (n = 15) treated with ceftriaxone alone, and in wt (n = 19) and TLR2-/- (n = 33) treated with TNF484 and ceftriaxone combined. Dashed and solid arrows indicate start of twice daily therapy with TNF484 and ceftriaxone, respectively.
