Fig. 5.

DNA alterations in the postischemic kidneys of WT, B2R-null, and B1RB2R-null mice. (A) The levels of 8-OHdG in total DNA of the kidney. (B) Relative proportion of D-17 deletions (as a percentage of WT) in the mtDNA. White and black columns indicate sham-operated and ischemia groups, respectively. The data are means ± standard errors, with the numbers of animals shown in white or black digits. ∗, P < 0.05 vs. the sham-operated group of the same genotype; †, P < 0.05 vs. WT; ‡, P < 0.05 vs. B2R-null.