Table 1.
FoxO targets in liver EC
| # of BE(s) | Conservation Score | # of 3-species BE(s) | CIS | validated by RT-qPCR | validated by ChIP | validated by ISH | |
|---|---|---|---|---|---|---|---|
| Downregulated FoxO Target Genes | |||||||
| Spry2 | 10 | 28 | 5 | YES | YES | YES | |
| Tcf4 | 10 | 27 | 4 | YES | nd | YES | |
| Klf6 | 10 | 28 | 3 | YES | nd | NO | |
| Cited2 | 6 | 17 | 2 | YES | YES | YES | |
| Adm | 5 | 15 | 2 | YES | YES | YES | |
| Ccrn4l | 4 | 12 | 1 | YES | YES | YES | |
| Hmga2 | 1 | 3 | 1 | nd | nd | nd | |
| Mrc1 | 1 | 3 | 1 | YES | YES | nd | |
| Ctgf | 1 | 3 | 1 | YES | YES | YES | |
| Upregulated FoxO Target Genes | |||||||
| Meis1 | 10 | 28 | 4 | Evi8 | YES | nd | NO |
| Pbx1 | 11 | 32 | 3 | YES | YES | YES | |
| Tsc22d1 | 3 | 9 | 2 | YES | nd | YES | |
| Ccnd1 | 8 | 25 | 1 | Ccnd1 | YES | nd | nd |
| Sdpr | 4 | 11 | 1 | YES | nd | YES | |
| Sepm | 4 | 12 | 1 | nd | nd | nd | |
| Fbn1 | 4 | 12 | 1 | YES | nd | YES | |
| Bmper | 4 | 12 | 1 | YES | YES | YES | |
| Rab34 | 3 | 9 | 1 | YES | nd | nd | |
| D0H4S114 | 3 | 9 | 1 | nd | nd | nd | |
| Pcolce | 2 | 6 | 1 | nd | nd | nd | |
| Id1 | 1 | 3 | 1 | YES | nd | YES | |
YES: validated
NO ; non-validated
nd: not determined