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Sequence context bias around the mutated G position. The ratio was calculated between the observed nucleotide occurrence around the G/C to A/T mutations in our screen (n = 973) and the expected frequency for a random G/C base pair in the complete coding part of the 32 genes that were screened (n = 11,740). Sequence data was analyzed with the G base centered on the 0 position of the positive DNA strand. *P < 0.001, #P < 0.05.
