Figure 3.

Schematic presentation of the predicted model of Darc protein based on analogy with the Il8 type A receptor (modified from Tournamille et al. 1997). The three cysteine residues that form the chemokine binding site are brought into close proximity by a disulfide bridge between the first and the fourth extracellular domains of the Darc protein. The cysteine residue at the N terminus that forms the bridge is at position 49 in the mouse Darc sequence. The position of the SNP G56D is indicated.