Table 1.

Summary of the ontogenic progression and effects of a single 24-h maternal deprivation and response to restraint in the 6-, 12- and 18-day-old animal

	Cortex			Amygdala			Septum			Hippocampus
Molecules	CRH	CRHbp	CRHr1	CRH	CRHbp	CRHr1	CRH	CRHbp	CRHr1	CRH	CRHbp	CRHr1
Ontogeny (0 time point, NDEP)
Postnatal day 6	Low	↑	Low	Low	Low	↑	Low	Low	Low-	Low CA1, CA3, DG	Low	Low CA1 Low CA3–4
Postnatal day 12	↑ ↑	↑ ↑	↑ ↑	↑	↑	No change	Low	No change	-Low-	No change	Low	↓ CA1 ↑ ↑ DG
Postnatal day 18	↑ ↑	↑ ↑	↓ ↓	↑ ↑	↑ ↑	No change	↓	No change	↓ ↓	No change	↓ CA1	↓ ↓ CA1 ↓ DG
Maternal deprivation (0 time point, DEP)
Postnatal day 6	NE	NE	NE	NE	NE	NE	NE	NE	NE	↑ CA1	NE	NE
Postnatal day 12	↓	NE	↓	NE	NE	NE	NE	NE	NE	↓CA1	NE	NE
Postnatal day 18	↓	NE	NE	NE	↓	NE	NE	NE	NE	NE	NE	↓CA3
Restraint response
Postnatal day 6	NE	NE	NE	↓DEP	NE	↓NDEP and DEP	↑	↑	↑NDEP	↓CA1 DEP	NE	↑CA1DEP, DG
Postnatal day 12	↓NDEP	↑NDEP and DEP	↓NDEP and DEP	↓NDEP and DEP	NE	↓NDEP	↑	↑	↑NDEP	↑DG	NE	↓CA1 DEP, CA3 NDEP and DEP, DG
Postnatal day 18	↑DEP	NE	NE	↓DEP	↓NDEP and DEP	↑NDEP	↑	↑	NE	NE	NE	↑CA3 DEP

NE=no effect.