Fig. 2. Overexpression of PACSIN3 in 3T3-L1 adipocytes promotes glucose uptake.
(A) Schematic diagram of the PACSIN3 constructs expressed through adenoviral expression. (B) 3T3-L1 adipocytes at day 4–5 after differentiation were infected with equal viral titers of beta-galactosidase (βgal), mycWTPACSIN3 (WT), mycΔC354PACSIN3 (ΔC354), mycΔC329PACSIN3 (ΔC329) or mycΔN244PACSIN3 (ΔN244) constructs; 3 days post-infection, cells were incubated with or without 1 μM insulin for 30 min, followed by the measurement of 2-deoxy-glucose uptake. *, p < 0.05 and **, p < 0.01 compared to the corresponding βgal control by Student T-test. Values are the mean ± standard error from three independent experiments.