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. Author manuscript; available in PMC: 2008 Jan 4.
Published in final edited form as: Neuron. 2007 Jan 4;53(1):53–64. doi: 10.1016/j.neuron.2006.11.023

Figure 4.

Figure 4

Hypoxia Shifts the Sensitivity of NMDA Receptor Inhibition Towards Lower Concentrations of NO

(A) Inhibition of NMDA responses by SNOC (5-500 μM) under ambient conditions. (B) Inhibition of NMDA responses by SNOC (5-500 μM) under hypoxic conditions. At each concentration of SNOC, hypoxic conditions augmented inhibition of NMDA-evoked currents greater than ambient air conditions. Remarkably, at lower concentrations of SNOC, inhibition of NMDA-evoked current was evident only under hypoxic conditions. (C) Potentiation of NMDA-evoked currents expressed as normalized responses to NMDA before SNOC application. Values are mean ± SEM (n = 7 in each case). SNOC inhibition of NMDA currents was significantly greater under hypoxic compared to ambient conditions (*p < 0.05, **p < 0.01; Mann-Whitney U test).