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. Author manuscript; available in PMC: 2008 Jan 4.
Published in final edited form as: Neuron. 2007 Jan 4;53(1):53–64. doi: 10.1016/j.neuron.2006.11.023

Figure 6.

Figure 6

Mutation of Cysteines 744, 798 of the NR1 Subunit Abrogates Hypoxic Enhancement of NO-Mediated Inhibition NMDA-Evoked Currents

(A and B) Voltage-clamp traces from oocytes expressing NR1(C744A, C798A)/NR2A subunits under ambient air (A) and hypoxic (B) condition. SNOC produced dose-dependent inhibition of NMDA-evoked currents (200 μM NMDA plus 10 μM glycine) under ambient air conditions but hypoxia did not enhance this inhibition. (C) Inhibition of NMDA-evoked currents by NO, expressed as normalized responses to NMDA before SNOC application. Values are mean ± SEM (n = 4-5 oocytes).