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. Author manuscript; available in PMC: 2007 Apr 24.
Published in final edited form as: J Biol Chem. 2005 Apr 18;280(24):23262–23272. doi: 10.1074/jbc.M503701200

FIG.5.

FIG.5

Reduction in ATM protein levels enables radiation activation of CS. LNCaP cells were transfected 96 h before irradiation, and CWR22-Rv1 cells were transfected 72 h before irradiation. Cells were preincubated with 40 μM FB1 where indicated for 3 h prior to irradiation. CS activation was quantified in LNCaP cells 3 h postirradiation (A) and in CWR22-Rv1 cells 16 h postirradiation (B). Shown are nontransfected cells (NT), sense-treated cells (S), and antisense-treated cells (AS). The graphs are representative of one of at least three separate experiments.