Table 4.

Location of single nucleotide polymorphisms in various SRF1A domains. Abbreviations: JM, juxtamembrane domain; LRR, leucine-rich repeat; PRR, proline-rich region; SP, signal peptide.

Polymorphism	SP	SUB Domain	LRR	PRR	JM	Kinase	C-Terminus
Synonymous	1	2	3	1	-	13	-
Non-synonymous	-	-	1	1	11*	12	1
Total	1	2	4	2	11	25	1

*Two of SNPs are located in the first and third codon position of a triplet

Ka/Ks = 0.25 (extracellular)

Ka/Ks = 1.84 (intracellular)

Abbreviations: JM, juxtamembrane domain; LRR, leucine-rich repeat; PRR, proline-rich region; SP, signal peptide.