Fig. 2.
Key interactions of the TRAP-tail with P. falciparum aldolase. (A) TRAP-tail residues D604, W605, and N606 (magenta) interacting with PfAldo residues (light blue). Cα positions are marked as spheres. Selected hydrophobic contacts are shown with red lines and distances in angstroms. The hydrogen bond between the indole nitrogen of TRAP-W605 and the carboxylate of E40, and the interactions between TRAP-N606 with R153 and K151, and of the backbone oxygen of TRAP-D604 with R48, are depicted in black. (B) Sequence alignment of the C-terminal TRAP-tail residues of three plasmodial species. Identical residues are shaded in red. All TRAP residues involved in contacts with aldolase are well conserved in several Plasmodium species.