Figure 7. Docked conformations of the four tetracycline derivatives related to residues 48–52 in the BOG binding site in the pre-fusion (gray) and post-fusion (blue) states.

(A) rolitetracycline, (B) doxycycline, (C) tetracycline, and (D) oxytetracycline. Atoms within the compounds are displayed using the CPK model (oxygen in red, nitrogen in blue, and carbon in gray). The side chains of certain residues that overlap with the compounds are displayed. The segments D′_o, k_o, and l_o are present in the pre-fusion conformation, while D′_c, k_c, and l_c are present in the post-fusion conformation.