TABLE 2.
Effects of single 200-mg/kg oral doses of selected synthetic trioxolanes administered to mice harboring a 21-day-old juvenile S. mansoni infection on worm burden, stratified by sex and worm distributiona
| Group | No. of mice investigated | No. of mice cured | Mean no. of worms (SD)
|
Total worm burden
|
Female worm burden
|
||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Liver | Mesenteric veins | Total | Males | Females | % Reduction | KW | P value | % Reduction | KW | P value | |||
| Control | 10 | 4.6 (3.4) | 36.4 (11.0) | 41.0 (9.5) | 17.9 (4.1) | 23.1 (6.7) | |||||||
| ST01 | 5 | 0 | 4.0 (2.0) | 34.8 (8.5) | 38.8 (9.3) | 16.6 (5.1) | 22.2 (6.3) | 5.4 | 0 | >0.999 | 3.9 | 0.18 | 0.666 |
| ST03 | 5 | 0 | 4.0 (2.5) | 38.6 (11.9) | 42.6 (10.7) | 19.0 (5.9) | 23.6 (5.8) | 0 | NA | NA | 0 | NA | NA |
| NP17 | 5 | 0 | 7.4 (3.4) | 41.0 (6.2) | 48.4 (6.2) | 22.8 (4.4) | 25.6 (3.6) | 0 | NA | NA | 0 | NA | NA |
| NP18 | 5 | 0 | 3.0 (2.3) | 37.2 (10.7) | 40.2 (10.6) | 18.2 (4.5) | 22.0 (6.1) | 2.0 | 0.03 | 0.853 | 4.8 | 0.03 | 0.853 |
| OZ01 | 5 | 0 | 4.0 (1.9) | 27.6 (11.7) | 31.6 (11.6) | 14.6 (6.0) | 17.0 (5.8) | 22.9 | 1.50 | 0.220 | 26.4 | 1.99 | 0.157 |
| OZ03 | 5 | 0 | 5.6 (2.7) | 1.8 (1.5) | 7.4 (4.0) | 2.6 (1.1) | 4.8 (3.3) | 82.0 | 9.42 | 0.002 | 79.2 | 9.44 | 0.002 |
| Control | 5 | 7.0 (1.9) | 30.2 (15.4) | 37.2 (15.7) | 21.5 (8.9) | 15.7 (7.8) | |||||||
| OZ78 | 3 | 0 | 4.7 (1.5) | 2.0 (3.5) | 6.7 (4.7) | 4.7 (2.9) | 2.0 (2.0) | 82.0 | 5.40 | 0.020 | 87.3 | 5.40 | 0.020 |
| Control | 7 | 2.7 (2.4) | 35.3 (7.0) | 38.0 (7.2) | 21.4 (4.4) | 16.6 (3.7) | |||||||
| OZ209 | 3 | 0 | 1.0 (0) | 6.0 (6.0) | 5.7 (1.5) | 3.0 (1.0) | 2.7 (0.6) | 85.0 | 5.72 | 0.017 | 83.7 | 5.79 | 0.016 |
| Control | 3 | 6.0 (2.0) | 53.0 (9.6) | 59.0 (9.5) | 29.3 (5.0) | 26.4 (3.8) | |||||||
| OZ288 | 5 | 0 | 2.0 (1.0) | 0.7 (1.2) | 2.7 (1.5) | 1.7 (1.2) | 1.0 (1.0) | 95.4 | 3.86 | 0.049 | 96.2 | 3.85 | 0.049 |
a
SD, standard deviation; KW, Kruskal-Wallis; NA, not applicable.