TABLE 3.
Effects of single 400-mg/kg oral doses of selected OZ compounds administered to mice harboring a 49-day-old adult S. mansoni infection on worm burden, stratified by sex and worm distributiona
| Group | No. of mice investigated | No. of mice cured | Mean no. of worms (SD)
|
Total worm burden
|
Female worm burden
|
||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Liver | Mesenteric veins | Total | Males | Females | % Reduction | KW | P value | % Reduction | KW | P value | |||
| Control | 10 | 0 | 3.2 (2.0) | 33.3 (8.0) | 38.5 (9.5) | 21.1 (4.9) | 17.4 (5.3) | ||||||
| OZ03 | 3 | 0 | 3.3 (2.5) | 24.0 (6.1) | 27.3 (6.7) | 15.0 (4.0) | 12.3 (2.9) | 29.1 | 2.88 | 0.089 | 29.3 | 1.41 | 0.235 |
| Control | 10 | 0 | 2.3 (2.5) | 16.4 (12.3) | 18.7 (13.7) | 10.7 (8.0) | 8.0 (5.9) | ||||||
| OZ78 | 5 | 0 | 1.6 (1.9) | 20.6 (13.5) | 22.2 (15.1) | 13.4 (9.3) | 8.8 (6.0) | 0 | NA | NA | 0 | NA | NA |
| OZ209 | 3 | 0b | 4.3 (2.1) | 11.3 (11.8) | 15.6 (13.4) | 9.7 (7.4) | 6.0 (6.1) | 16.6 | 0.06 | 0.799 | 25.0 | 0.47 | 0.493 |
| Control | 5 | 0 | 6.4 (3.8) | 29.2 (7.2) | 35.6 (5.4) | 22.2 (4.0) | 13.4 (2.7) | ||||||
| OZ288 | 3 | 0 | 4.0 (1.7) | 13.0 (11.4) | 17.0 (10.4) | 12.3 (7.6) | 4.7 (3.1) | 52.2 | 4.46 | 0.034 | 64.9 | 5.0 | 0.025 |
a
SD, standard deviation; KW, Kruskal-Wallis; NA, not applicable.
b
Two mice died 48 to 96 h after treatment.