TABLE 5.
Dose-response relationship of OZ78 and OZ288 against 49-day-old adult S. mansoni harbored in hamstersa
| Group | Dose (mg/kg) | No. of hamsters investigated | No. of hamsters cured | Mean no. of worms (SD)
|
Total worm burden
|
Female worm burden
|
||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Liver | Mesenteric veins | Total | Males | Females | % Reduction | KW | P value | % Reduction | KW | P value | ||||
| Control | 7 | 0 | 6.7 (4.2) | 45.1 (9.0) | 51.9 (10.4) | 29.7 (6.5) | 22.1 (4.9) | |||||||
| OZ78 | 50 | 4b | 0 | 3.5 (2.1) | 24.5 (16.3) | 28.0 (18.4) | 14.5 (10.6) | 13.5 (7.8) | 46.1 | 3.08 | 0.079 | 38.9 | 2.16 | 0.141 |
| 100 | 4 | 0 | 4.5 (4.5) | 11.5 (6.1) | 16.0 (9.7) | 11.5 (6.4) | 4.5 (3.7) | 69.2 | 7.00 | 0.008 | 79.6 | 7.03 | 0.008 | |
| 200 | 4 | 0 | 2.0 (0.8) | 5.8 (3.5) | 7.8 (3.8) | 6.3 (2.4) | 1.5 (1.7) | 85.0 | 7.00 | 0.008 | 93.2 | 7.06 | 0.008 | |
| OZ288 | 50 | 3 | 0 | 4.0 (1.7) | 23.7 (16.8) | 27.7 (18.1) | 13.3 (10.1) | 14.0 (8.2) | 46.6 | 3.32 | 0.067 | 36.7 | 1.31 | 0.251 |
| 100 | 3 | 0 | 2.7 (2.3) | 21.0 (7.0) | 24.7 (5.9) | 11.7 (2.5) | 13.0 (3.5) | 52.4 | 5.72 | 0.016 | 41.2 | 5.79 | 0.016 | |
| 200 | 3 | 0 | 2.0 (2.6) | 11.7 (14.2) | 14.7 (15.9) | 8.0 (8.7) | 6.7 (7.2) | 71.7 | 5.72 | 0.016 | 69.7 | 5.76 | 0.016 | |
a
SD, standard deviation; KW, Kruskal-Wallis.
b
Two hamsters were not infected and, hence, they were excluded from the analysis.