TABLE 6.
Effect of a single oral dose of OZ78 administered to hamsters and rabbits harboring a 49-day-old adult S. japonicum infectiona
| Animal host | Group | Dose (mg/kg) | No. of animals investigated | No. of animals cured | Mean no. of worms (SD)
|
Total worm burden
|
Female worm burden
|
||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Total | Males | Females | % Reduction | KW | P value | % Reduction | KW | P value | |||||
| Hamster | Control | 6 | 69.0 (13.1) | 35.0 (6.2) | 33.7 (6.8) | ||||||||
| OZ78 | 200 | 4 | 2 | 4.0 (4.9) | 4.0 (4.9) | 0 | 94.2 | 6.63 | 0.010 | 100 | 6.96 | 0.008 | |
| Rabbit | Control | 4 | 97.0 (16.4) | 50.3 (7.8) | 46.8 (8.8) | ||||||||
| OZ78 | 15 | 4 | 0 | 57.5 (32.0) | 30.5 (16.5) | 27.0 (15.6) | 40.7 | 4.08 | 0.043 | 42.3 | 3.00 | 0.083 | |
a
SD, standard deviation; KW, Kruskal-Wallis.