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Affinities of BATSIs and a reference compound for β-lactamases
| β-Lactamase |
Ki (μM) of:
|
||
|---|---|---|---|
| Cefotaxime BATSI | Ceftazidime BATSI | Reference compound | |
| SHV-1 | 8.9 ± 0.9 | 2.2 ± 0.2 | 300 ± 15 |
| SHV-2 | 3.4 ± 0.7 | 6.8 ± 0.9 | 330 ± 10 |
| SHV-5 | 5.0 ± 0.5 | 4.5 ± 0.5 | 360 ± 20 |
| D104K | 5.0 ± 0.5 | 0.7 ± 0.1 | 190 ± 20 |
| G238S D104K | 1.1 ± 0.2 | 4.5 ± 0.3 | 300 ± 30 |
