. 2007 Feb 12;51(4):1414–1424. doi: 10.1128/AAC.01312-06

TABLE 5.

Results of rechallenge of ferrets with a lethal dose of homologous H5N1 virus after completion of oseltamivir treatment

Virus	Oseltamivir regimen	Rechallenge virus dose (EID₅₀/ferret)^a	Range of prechallenge HI titers^b			No. of ferrets that survived/total no.	No. of ferrets with clinical signs of disease/total no.^c
Virus	Oseltamivir regimen	Rechallenge virus dose (EID₅₀/ferret)^a	A/Vietnam/1203/04	A/HK/213/03	A/Turkey/15/06	No. of ferrets that survived/total no.	No. of ferrets with clinical signs of disease/total no.^c
A/Vietnam/1203/04	25 mg/kg/day, 24-h delay	10²	20-40	80-160	NT	3/3	0/3
A/Turkey/15/06	10 mg/kg/day, 24-h delay	10⁷	20-40	320-640	160-320	3/3	0/3

Three weeks after the initial H5N1 virus inoculation, surviving oseltamivir-treated ferrets were reinoculated with 10² EID₅₀ of A/Vietnam/1203/04 or 10⁷ EID₅₀ of A/Turkey/15/06 virus.

HI titers against homologous and heterologous viruses 3 weeks after initial inoculation (expressed as reciprocal values, e.g., 40 versus 1:40). NT, not tested.

Clinical signs of disease were weight loss, temperature increase, respiratory signs, and inactivity index. Nasal washes were collected on day 3 p.i. All were below the level of detection (<0.75 log₁₀ EID₅₀/ml).