TABLE 2.
Summary of the geometric mean (90% CI) steady-state pharmacokinetic parameters for ATV, SQV, and RTV, including GMR and P values (two-sided ANOVA) for the differences between groups
| Drug | Group and regimen (no. of patients) | Parameter [GM (90% CI)]
|
|||||
|---|---|---|---|---|---|---|---|
| Cmin (ng/ml) | Cmax (ng/ml) | AUCss (ng·h/ml) | t1/2 (h) | Tmax (h) | Tlag (h) | ||
| ATV | 1, SQV/RTV (49) | 515 (440, 604) | 3,488 (3,081, 3,949) | 39,154 (34,255, 44,752) | 7.64 (7.12, 8.19) | 2.43 (1.52, 2.90) | 0.47 (0.29, 0.76) |
| 2, RTV/NRTI (72) | 428 (390, 503) | 2,924 (2,869, 3,366) | 33,626 (31,143, 38,431) | 8.06 (7.73, 8.63) | 2.67 (1.92, 2.83) | 0.51 (0.42, 0.72) | |
| 1 vs 2 | 1.21 (1.14, 1.55) | 1.20 (1.09, 1.38) | 1.16 (1.12, 1.44) | 0.94 (0.82, 0.95) | 0.91 (0.53, 1.51) | 0.92 (0.40, 1.81) | |
| SQV | 1, ATV/RTV (49) | 438 (357, 537) | 3,257 (2,869, 3,697) | 22,794 (19,959, 26,032) | 4.52 (4.28, 4.76) | 2.94 (2.70, 3.21) | 1.02 (0.84, 1.24) |
| 3, RTV/NRTI (90) | 437 (374, 512) | 2,331 (2,069, 2,627) | 15,759 (13,880, 17,892) | 3.86 (3.67, 4.06) | 2.95 (1.97, 3.22) | 0.78 (0.63, 0.97) | |
| 1 vs 3 | 1.00 (0.70, 1.53) | 1.40 (1.09, 1.79)a | 1.45 (1.12, 1.88)a | 1.17 (1.05, 1.30)a | 1.00 (0.84, 1.63) | 1.31 (0.87, 1.97) | |
| RTV | 1, ATV/SQV (49) | 29 (24, 35) | 1,050 (933, 1,183) | 8,100 (7,076, 9,270) | 3.76 (3.52, 4.01) | 2.67 (1.65, 3.22) | 0.30 (0.17, 0.54) |
| 2, ATV/NRTI (72) | 50 (47, 58) | 943 (931, 1,092) | 8,450 (8,239, 9,586) | 4.82 (4.63, 5.08) | 2.70 (1.66, 2.61) | 0.16 (0.13, 0.28) | |
| 3, SQV/RTV (90) | 231 (208, 251) | 970 (878, 1,071) | 6,899 (6,286, 7,573) | 3.85 (3.65, 4.05) | 3.34 (1.97, 3.57) | 0.55 (0.36, 0.85) | |
| 1 vs 2 | 0.58 (0.41, 0.74)c | 1.11 (0.87, 1.24) | 0.96 (0.74, 1.13) | 0.78 (0.69, 0.87)b | 0.99 (0.63, 1.94) | 1.88 (0.61, 4.15)c | |
| 1 vs 3 | 0.13 (0.10, 0.17)c | 1.08 (0.87, 1.24) | 1.17 (0.93, 1.47) | 0.98 (0.87, 1.10) | 0.80 (0.46, 1.63)b | 0.55 (0.20, 1.50)c | |
a
Statistically significant; P < 0.05.
b
P < 0.01.
c
P < 0.001 (two-sided ANOVA).