TABLE 1.

Simulated linezolid dosage regimens

Regimen no.	Simulated human regimen	Targeted concn	In vitro regimena	Targeted PK/PD valuesb
				AUC/MIC	%TMIC
1	600 mg q12h	Cmax, 20 μg/mlc; Cmin, 3.8 μg/ml	5.8-mg loading dose + 4.7-mg maintenance dose q12h	120	100
2	120 mg/24 h	Continuous maintenance of 2.0 μg/ml	2.0-μg/ml continuous infusion	24	100
3	120 mg q12h	Cmax, 4.0 μg/ml; Cmin, 0.76 μg/ml	1.2-mg loading dose + 0.94-mg maintenance dose q12h	24	42
4	30 mg/24 h	Continuous maintenance of 0.50 μg/ml	0.50-μg/ml continuous infusion	6	0

^aVolume of distribution, 290 ml; half-life, 5 h.

^bMIC of 2 μg/ml for all strains.

^cApproximating C_max (for the total plasma concentration) (Zyvox product information, 21 February 2002).