TABLE 1.
Parasitological cure and mortality rates and mean survival times of WT, IFN-γ-KO, and IL-12-KO mice infected with T. cruzi strain Y and treated with posaconazole and benznidazole
| Mice | Untreated
|
Benznidazole
|
Posaconazole
|
||||||
|---|---|---|---|---|---|---|---|---|---|
| Mortality (no. of mice that died/total no. tested [%]) | Mean survival time (days) | Curea (no. of mice cured/total no. tested [%]) | Mortality (no. of mice that died/total no. tested [%]) | Mean survival time (days) | Cure (no. of mice cured/total no. tested [%]) | Mortality (no. of mice that died/total no. tested [%]) | Mean survival time (days) | Cure (no. of mice cured/total no. tested [%]) | |
| WT | 20/22 (91)f | 21.2 ± 1.1 | 0/22 (0) | 0/29 (0) | (>60) | 25/29 (86) | 0/18 (0) | >60 | 16/18 (89) |
| IFN-γ KO | 15/15 (100) | 13.5 ± 0.3b | 0/15 (0) | 15/15 (100) | (42.1 ± 0.8)c | 0/15 (0) | 6/20 (30) | 52.1 ± 1.1c,d,f | 3/20 (15) |
| IL-12 KO | 11/11 (100) | 12.3 ± 0.6b | 0/11 (0) | 3/18 (17) | (59.6 ± 0.6)e,f | 7/18 (39) | 4/17 (23) | 59.2 ± 0.6e,f | 6/17 (35) |
Proportion of the number of mice with negative parasitemia to the number of mice examined by fresh blood examination and hemoculture after chemotherapy.
P < 0.0001 compared with the results for the WT untreated control. All P values were determined by the log rank and Peto-Peto-Wilcoxon tests.
P < 0.0001 compared with the results for the IFN-KO untreated control.
P < 0.0001 compared with the results for the IFN-KO BZ-treated animals.
P < 0.0001 compared with the results for the IL-12-KO untreated control.
Biased results because the mean survival times were calculated assuming that the death (failure) time of the survivors was exactly 60 days. They provide a subestimation of the true mean survival times when the observation period is limited.