FIG. 1.
In vitro activities of different concentrations of drugs against biofilms formed by four individual bloodstream isolates representing four different Candida species. Symbols: ×, C. albicans; ▵, C. parapsilosis; ⧫, C. tropicalis; □, C. glabrata. The inhibitory effect of each concentration of antifungal was measured as the average OD of all antifungal-treated wells and expressed as a percentage of the OD of control (antifungal-free) wells (considered to be 100%) as determined in XTT reduction assays. Species-specific differences are evident for the activities of caspofungin and micafungin against Candida biofilms (P < 0.05), in contrast to the activities of fluconazole and amphotericin B. SMIC50, MIC50 for sessile cells; SMIC80, MIC80 for sessile cells.