TABLE 3.
Distribution of caspofungin and micafungin MICs for different Candida species strains under planktonic or biofilm growth conditions
| Drug | Species | No. of isolates tested | Type of MICa | No. of isolates for which indicated MIC (μg/ml) was:
|
||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 0.03 | 0.06 | 0.12 | 0.25 | 0.5 | 1 | 2 | 4 | 8 | 16 | >16 | ||||
| Caspofungin | C. albicans | 12 | MIC for planktonic cells | 6 | 4 | 2 | ||||||||
| MIC50 for sessile cells | 1 | 1 | 1 | 9 | ||||||||||
| MIC80 for sessile cells | 9 | 3 | ||||||||||||
| C. parapsilosis | 12 | MIC for planktonic cells | 6 | 5 | 1 | |||||||||
| MIC50 for sessile cells | 1 | 2 | 2 | 2 | 5 | |||||||||
| MIC80 for sessile cells | 12 | |||||||||||||
| C. tropicalis | 10 | MIC for planktonic cells | 4 | 5 | 1 | |||||||||
| MIC50 for sessile cells | 6 | 2 | 2 | |||||||||||
| MIC80 for sessile cells | 10 | |||||||||||||
| C. glabrata | 9 | MIC for planktonic cells | 2 | 5 | 2 | |||||||||
| MIC50 for sessile cells | 1 | 1 | 6 | 1 | ||||||||||
| MIC80 for sessile cells | 3 | 6 | ||||||||||||
| Micafungin | C. albicans | 12 | MIC for planktonic cells | 12 | ||||||||||
| MIC50 for sessile cells | 2 | 6 | 3 | 1 | ||||||||||
| MIC80 for sessile cells | 1 | 2 | 6 | 3 | ||||||||||
| C. parapsilosis | 12 | MIC for planktonic cells | 3 | 7 | 2 | |||||||||
| MIC50 for sessile cells | 2 | 5 | 1 | 4 | ||||||||||
| MIC80 for sessile cells | 1 | 11 | ||||||||||||
| C. tropicalis | 10 | MIC for planktonic cells | 10 | |||||||||||
| MIC50 for sessile cells | 1 | 1 | 1 | 1 | 1 | 1 | 4 | |||||||
| MIC80 for sessile cells | 1 | 9 | ||||||||||||
| C. glabrata | 9 | MIC for planktonic cells | 9 | |||||||||||
| MIC50 for sessile cells | 2 | 6 | 1 | |||||||||||
| MIC80 for sessile cells | 3 | 2 | 2 | 1 | 1 | |||||||||
a
MIC50s and MIC80s were determined by measuring XTT activity reduction.