TABLE 3.
Determinations of frequency of resistance to PD 0305970
| Organism and drug | MIC
|
|||
|---|---|---|---|---|
| 1× | 2× | 4× | 8× | |
| S. aureus UC-76 (SA-1) | ||||
| PD 0305970 (MIC = 0.03 μg/ml) | 5 × 10−7 | 3 × 10−7 | < 6 × 10−8 | <6 × 10−8 |
| Ciprofloxacin (MIC = 0.125 μg/ml) | TNTC | TNTC | 3 × 10−7 | <6 × 10−8 |
| Levofloxacin (MIC = 0.125 μg/ml) | Not tested | Not tested | 8.9 × 10−9 | Not tested |
| S. pneumoniae 7785 (SP-2870) | ||||
| PD 0305970 (MIC = 0.03 μg/ml) | <6 × 10−10 | <6 × 10−10 | <6 × 10−10 | <6 × 10−10 |
| Ciprofloxacin (MIC = 1 μg/ml) | 6 × 10−10 | 1 × 10−9 | <6 × 10−10 | <6 × 10−10 |
| Gatifloxacin (MIC = 0.25 μg/ml) | Not tested | 3 × 10−8 | <1 × 10−9 | <1 × 10−9 |
| Levofloxacin (MIC = 0.5 μg/ml) | Not tested | Not tested | 1.2 × 10−10 | Not tested |