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Mutations identified in the quinolone resistance-determining region (gyrA, gyrB, parC, and parE) of S. pneumoniae 7785 selected by PD 0305970
| Strain | MIC (μg/ml) of PD 0305970 | Mutation in QRDRa
|
|||
|---|---|---|---|---|---|
| gyrA | gyrB | parC | parE | ||
| 7785 | 0.03 | None | None | None | None |
| 1-970-1 | 0.06 | None | Asp435Glu | None | None |
| 1-970-2 | 0.125 | None | Asp435Glu Glu475Ala | None | Pro475Ser |
QRDR, quinolone resistance-determining region.
