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Efficacy in a murine pneumococcal pneumonia model
| Infecting organism | Treatment | PD50a ± 95% confidence limit (mg/kg) (MIC [μg/ml])
|
|
|---|---|---|---|
| PD 0305970 | Levofloxacin | ||
| Streptococcus pneumoniae SVI | QD × 1 day | 3.2 ± 3.8 (0.008) | 69 ± 37 (0.5) |
| S. pneumoniae SP-4333 (quinolone resistant) | BID × 3 days | 4.1 ± 1.4 (0.03) | >200 (32) |
PD50, oral drug dose protecting 50% of challenged mice from lethal bacterial infection.
