TABLE 2.
Comparison of daptomycin MIC results obtained by the Etest and the broth microdilution method against 212 unusual gram-positive bacterial isolates
| Organism (no. of isolates) | No. (%) of isolates for which the Etest MIC differed from the broth microdilution MIC by the following number of log2 dilutions:
|
Mean difference | 95% CIa | Agreement (%)b | ||||||
|---|---|---|---|---|---|---|---|---|---|---|
| ≤−3 | −2 | −1 | 0 | 1 | 2 | ≥3 | ||||
| L. monocytogenes (31) | 0 (0) | 0 (0) | 2 (6.5) | 18 (58.1) | 10 (32.3) | 1 (3.2) | 0 (0) | 0.32 | 0.083-0.56 | 96.7 |
| Pediococcus spp. (13) | 0 (0) | 0 (0) | 5 (38.5) | 7 (53.8) | 0 (0) | 1 (7.7) | 0 (0) | −0.23 | −0.73-0.27 | 92.3 |
| Leuconostoc spp. (68) | 3 (4.4) | 8 (11.8) | 26 (38.2) | 25 (36.8) | 5 (7.4) | 1 (1.5) | 0 (0) | −0.64 | −0.88-−0.40 | 82.3 |
| Rhodococcus spp. (21) | 0 (0) | 0 (0) | 3 (14.3) | 17 (81.0) | 1 (4.8) | 0 (0) | 0 (0) | −0.10 | −0.29-0.10 | 100 |
| Nocardia spp. (79) | 0 (0) | 2 (2.5) | 2 (2.5) | 74 (93.7) | 0 (0) | 1 (1.3) | 0 (0) | −0.05 | −0.14-0.04 | 96.2 |
a
CI, confidence interval.
b
Percentage of isolates with Etest MICs within 1 log2 dilution of broth dilution MICs.