TABLE 2.
In vivo abilities of polyamine analogues to prevent an infectiona
| SSAT inhibitor | ADC/ODC inhibitor | No. of animals shedding oocysts/total no. of animals | Mean infectivity score + SEM (no. of determinations) |
|---|---|---|---|
| None | None | 8/8 | 1.36 ± 0.12 (8) |
| None | DFMA | 4/8 | 0.69 ± 0.14 (8) |
| None | DFMO | 8/8 | 1.29 ± 1.29 (8) |
| CGC-11157 | None | 4/8 | 0.54 ± 0.16 (8) |
| CGC-11157 | DFMA | 0/8 | 0.08 ± 0.02b (8) |
| CGC-11157 | DFMO | 4/8 | 0.71 ± 0.12 (8) |
| CGC-11047 | None | 6/8 | 1.01 ± 0.14 (8) |
| CGC-11047 | DFMA | 4/8 | 0.86 ± 0.21 (8) |
| Paromomycin (positive control) | 3/6 | 0.78 ± 0.14 (6) |
a
Mice (six or eight per group) were treated once daily with 20 mg/kg of the test compound either alone or in equal combinations for 2 days prior to infection with 2 × 104 oocysts. Treatment was continued for 5 days using the same dose. Paromomycin was used at 100 mg/kg. Ten days posttreatment, mice were evaluated for oocyst shedding.
b
Significantly different from controls (P < 0.05).