TABLE 2.
Summary of covariate-model building for the clearance-based modela
| Function and model | Step | Parameter | Covariate added | Covariate removed | MVOF | MVOF change | df | P value |
|---|---|---|---|---|---|---|---|---|
| Forward selection (basic structural model) | 0 | 320 | ||||||
| 1 | V | Wt | 197 | −123 | 1 | <0.0001 | ||
| 2 | CL | BSA | 91.2 | −106 | 1 | <0.0001 | ||
| 3 | CL | Age | 87.1 | −4.10 | 1 | 0.04 | ||
| 4 | NS | NS | ||||||
| Backward elimination (full multivariable model) | 0 | 87.1 | ||||||
| 1 | CL | Age | 91.2 | 4.10 | 1 | 0.04 | ||
| 2 | SS | SS |
a
NS, none of the remaining covariates were statistically significant (P < 0.05); SS, all of the remaining covariates were statistically significant (P < 0.001); MVOF, minimum value of the objective function; MVOF change, change in the MVOF relative to that of the comparator model.