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. 2007 Jan 29;51(4):1341–1350. doi: 10.1128/AAC.01278-06

FIG. 1.

FIG. 1.

Schedule of antimicrobial treatments and evolution of resistance profiles of two intubated patients colonized by P. aeruginosa. Isolates of P. aeruginosa were cultured from tracheal aspirates during a period of 92 days for patient A (A) and 43 days for patient B (B). Day zero (D0) is the first day of detection of P. aeruginosa. Episodes of VAP and periods of antimicrobial treatments are indicated. For each patient, one tracheal aspirate was collected on each of the 18 days specified. The resistance profile of the most resistant isolate among those cultured from each tracheal aspirate is shown. Symbols designate susceptible (open squares), intermediate (gray squares), and resistant (black squares) isolates, according to CLSI breakpoints. Pip, piperacillin; Pip/Taz, piperacillin-tazobactam; Caz, ceftazidime; Cef, cefepime; Imi, imipenem; Mer, meropenem; Azt, aztreonam; Am, amikacin; Gm, gentamicin; Net, netilmicin; Tm, tobramycin; Nor, norfloxacin; Cip, ciprofloxacin. Asterisks indicate small-colony variants.