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Alignment of amino acid sequences for selected TK homologs. Amino acid sequences of TK homologs are shown for cowpox virus (NP_619890), vaccinia virus (YP_232976), variola virus (NP_042123), and human TK1 (AAH07986) with the consensus sequence shown below. In the consensus line, text in dark blue boxes represents the significant differences in the loop next to the active site residue Arg45. Text highlighted in gray denotes amino acid differences within 12 Å of the bound inhibitor dTTP.
