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Model of VV TK structure derived from the crystal structure of 1XBT by blastp (www.ncbi.nlm.nih.gov). Modeled J2R TK structure is shown in magenta overlaid on the reported structure of human TK1 1XBT (green). The modeled side chain of Arg45 (yellow) was shown to overlap with the bound dTTP in 1XBT. Orange dots represent the amino acid differences near the active site. The drawing was created with the program PyMol (Delano Scientific, San Carlos, CA).
