TABLE 4.
Activity of EDP-420 in combination with mefloquine against M. avium in mice
| Regimena | Dose (mg/kg) | Mice (n) | Bacterial load (CFU/g ± SEM) in:
|
|
|---|---|---|---|---|
| Liver | Spleen | |||
| Mefloquine | 40 | 13 | 1.8 × 107 ± 0.7 × 107b | 4.8 × 107 ± 2.2 × 107b |
| EDP-420 | 100 | 15 | 1.2 × 107 ± 0.4 × 107b | 1.7 × 107 ± 0.5 × 107b |
| Mefloquine + EDP-420 | 40 + 100 | 14 | 1.3 × 107 ± 0.4 × 107b | 1.6 × 107 ± 0.6 × 107b |
| Untreated control | 15 | 1.1 × 109 ± 0.4 × 109 | 2.4 × 109 ± 0.9 × 109 | |
| Baseline (7 days) | 9 | 2.5 × 107 ± 1.3 × 107 | 1.2 × 108 ± 0.9 × 108 | |
a
Mice were treated daily, 6 days a week, for 4 weeks.
b
P < 0.05 compared with untreated control.